Fig. 7: No apparent effects of SF1 neurons or their projections to PVT on anxiety. | Nature Communications

Fig. 7: No apparent effects of SF1 neurons or their projections to PVT on anxiety.

From: An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake

Fig. 7

Anxiety-related behavior in the open field test was performed on mice transduced with hM3Dq or mCherry in the SF1 neurons. a Representative traces of open field behavioral tests in mice treated with J60 via i.p. injections in mCherry and hM3Dq-transduced mice, or via intra-PVT injections. Group data of b time spent in the center of the open field (mCherryip J60, n = 16; hM3Dqip J60, n = 15; hM3Dqintra-PVT J60, n = 14). c Total distance traveled (mCherryip J60, n = 16; hM3Dqip J60, n = 15; hM3Dqintra-PVT J60, n = 14). d Mean speed (mCherryip J60, n = 16; hM3Dqip J60, n = 15; hM3Dqintra-PVT J60, n = 14) and e percent center distance (mCherryip J60, n = 16; hM3Dqip J60, n = 15; hM3Dqintra-PVT J60, n = 14). One-way ANOVA with Turkey post hoc tests; data represent mean ± s.e.m.; n.s. not significant.

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