Fig. 10: ManN promotes retinal neovascularization in mice. | Nature Communications

Fig. 10: ManN promotes retinal neovascularization in mice.

From: Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways

Fig. 10

a Intravitreal injection of ManN increases blood vessel density. Adult mice were intravitreally injected once 500 ng of ManN, Kif or 200 ng of bFGF. PBS was used as vehicle control. Seven days after injection, PFA-fixed retinas were subjected to CD31 immunofluorescence. Representative images of CD31-positive vessels are shown. n = 10 animals/treatment group, 3 independent experiments, scale bar = 50 µm. b Vascular density was determined with ImageJ software, n = 10 animals/treatment group, 3 independent experiments. Data were means +/− SEM. Statistical analysis was done by two-tailed, two-sample unequal variance t test. *p < 0.05, **p < 0.01, ***p < 0.001. Data are provided as a Source data file.

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