Fig. 1: Structure, function and polymerisation of AAT.
From: High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin
a Schematic indicating the position of N-linked glycans (with the abundant M6 glycoform shown)45, disease-associated mutations and the reactive centre loop. b Crystal structures of recombinant AAT highlighting key structural features and the location of disease-associated mutations, and the large-scale conformational changes associated with function and dysfunction: 1QLP72, 1EZX73, 1IZ274 and an adaptation of 3T1P7.
