Fig. 2: HelD architecture.
From: The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling
a Cartoon plot of HelD colored by domains (for color coding see legend). Numbers refer to domain borders. b Comparison of HelDNTR to GreB (PDB ID 6RIN) reveals similar topology of the coiled-coils, which insert into the secondary channel, and the globular domains; in GreB, the latter is responsible for high-affinity binding to the RNAP β′ rim helices. HelDNTR and GreB are rainbow-colored (blue, N-termini; red, C-termini). Numbers refer to domain borders. c Comparison of NTPase domains in HelD and in E. coli UvrD (PDB ID 2IS6). The D1-D2 regions are rainbow-colored (blue, N-termini; red, C-termini) as indicated in the legends. Neighboring and inserted regions (Ins), gray. Numbers refer to domain borders.
