Fig. 5: Transcriptome-immune networks associated with immune-intratumoural heterogeneity (ITH). | Nature Communications

Fig. 5: Transcriptome-immune networks associated with immune-intratumoural heterogeneity (ITH).

From: Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Fig. 5

a, b Transcriptome-immune network showing correlation between the immune subsets and the tumour transcriptome associated with a low or b high immune-ITH. Green and red lines denote positive and negative correlation, respectively (Spearman’s correlation test, ρ ≥ 0.4, P < 0.05). The immune subsets are denoted as red: cytotoxic/activated; blue: immunosuppressive/exhausted; and brown: controversial roles. c DAVID pathway enrichment analysis of the genes enriched in tumours with low or high immune-ITH. d Volcano plot showing DEGs with selected genes as highlighted in the low and high immune-ITH tumours. The orange line denotes the false discovery rate (FDR) = 0.01. Source data are provided as a Source Data file.

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