Fig. 9: SOX2 NLS regions adopt different conformations when bound to importins or nucleosomes. | Nature Communications

Fig. 9: SOX2 NLS regions adopt different conformations when bound to importins or nucleosomes.

From: Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

Fig. 9

a To gain access to the nucleus, SOX2 binds IMPα3 with the NLS regions in an extended conformation to form a single interface. b When localized to the nucleus, these regions adopt a closed conformation for optimal DNA binding36. c The regions are mutually exclusive and may suggest a possible release mechanism.

Back to article page