Fig. 7: Schematic representation of the effect of TgAP2IX-5 depletion on daughter cell formation according to the different phases of the cell cycle. | Nature Communications

Fig. 7: Schematic representation of the effect of TgAP2IX-5 depletion on daughter cell formation according to the different phases of the cell cycle.

From: TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii

Fig. 7

Absence of TgAP2IX-5 leads to the blockage of the cell cycle within the G1/S phase. This is associated with the direct targeting of key inner membrane complex proteins such as TgISP1, TgIMC1, TgIMC29, TgIMC3, and TgIMC4 as well as other key TFs (TgAP2XII-2, TgAP2XII-9, TgAP2III-2, TgAP2IV-4, TgAP2X-9). TgAP2IV-4 is a known repressor of differentiation. TgAP2X-9 may be repressed by TgAP2IX-5. The TgAP2IX-5 transcript may also be regulated by a negative feedback loop.

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