Fig. 3: The interface between hnRNPA1 LC protofilaments. | Nature Communications

Fig. 3: The interface between hnRNPA1 LC protofilaments.

From: The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

Fig. 3

a The primary sequence of the hnRNPA1 fibril core. The green bar marks the region of the interface between protofilaments. Residues forming the steric zipper in the interface are highlighted in blue. Residues forming π-stacking and hydrophobic interactions flanking the steric zipper are highlighted in orange. b Top view of the hnRNPA1 LC fibril structure. Side chains that are involved in the interactions between protofilaments are shown in spheres. Among them, the polar side chains in the steric zipper are colored in blue; the Phe and Pro side chains are colored in orange. The two protofilaments are colored in magenta and gray, respectively. The framed regions are zoomed in and shown in top and side views in c–e.

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