Fig. 6: Viral load analysis in organs of rVSV-∆G-spike vaccinated hamsters following SARS-CoV-2 challenge.
From: A single dose of recombinant VSV-∆G-spike vaccine provides protection against SARS-CoV-2 challenge
a Body weight changes of SARS-CoV-2 infected hamsters (5 × 106 pfu) 25 days post vaccination with 1 × 106 pfu, or unvaccinated. Arrows indicate 3 and 7 dpi—hamsters were sacrificed. Number of animals per group: days 0–3 n = 15, days 4–7 n = 7, days 8–12 n = 3. Statistical significance was performed by using two-tailed one unpaired t-test per row, with correction for multiple comparisons using Holm–Sidak method, *p < 0.005. Viral loads in lungs (b) and nasal turbinates (c) at 3 dpi of hamsters infected with SARS-CoV-2 (5 × 106 pfu/hamster, n = 4), and hamsters vaccinated with rVSV-∆G-spike (106 pfu/hamster), followed by infection with SARS-CoV-2 (5 × 106 pfu/hamster, n = 4). LOD: 75 pfu/lung, 50 pfu/nasal turbinates. Data for a–c are presented as mean values ± SEM. Significance analysis for b and c was performed using two-tailed unpaired Mann–Whitney nonparametric test, *p = 0.0286. Source data are provided as a Source Data file.
