Table 1 TEM-1 mutations in ceftazidime resistant (CAZR) clones.

From: In vivo diversification of target genomic sites using processive base deaminase fusions blocked by dCas9

Amino acid changea

Transition

CAZ (µg ml−1)

  

1

16

S4N

G to A

0

1

V33I

G to A

0

3

E104K

G to A

0

12

E110K

G to A

0

1

V119I

G to A

0

1

A150T

G to A

0

2

R164C

C to T

4

0

R164H

G to A

8

12

P174S

C to T

0

1

A249V

C to T

1

0

V262I

G to A

0

1

G267R

G to A

1

0

  1. aResidues numbered according to Ambler et al.59.
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