Fig. 7: Schematic figure showing possible mechanism of H3K27me2 and H3K27me3 establishment in mouse zygotes.
From: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome
We propose that EHMT1 is a new contributor to the formation of H3K27me2, and H3K27me2 might be a necessary prerequisite for the re-modification of H3K27me3 in the male pronucleus. The SET domain rather than the catalytic activity of EHMT1 is indispensable for de novo H3K27me2 in mouse zygotes. In addition, EZH2 is indispensable for the formation of H3K27me3 in mouse zygotes, and EZH2 is regulated by CDK1 in a cell cycle-dependent manner. However, Ezh1 and EZH2 have a synergistic effect on the establishment of de novo H3K27me2 in the paternal pronucleus of mouse zygote.
