Fig. 4: PA detection of CNV in living rabbits using CGNP clusters-RGD. | Nature Communications

Fig. 4: PA detection of CNV in living rabbits using CGNP clusters-RGD.

From: Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging

Fig. 4

a and b PAM images of CNV before and after the injection of 0.5 mL CGNP clusters-RGD at concentration of 2.5 mg/mL acquired along the selected area outlined in fundus image d under nanosecond pulsed laser illumination at wavelength of 578 and 650 nm, respectively. c Overlay 3D images showed the distribution of CGNP clusters-RGD accumulated at CNV location in rabbit retina (pseudo-green color). e Rabbit injected with CGNP clusters-RGD exhibited significantly higher PA signal than pre-injection. Note that the peak PA signal occurred at 24 h post injection. Then, the PA signals gradually decreased over time. f In vivo photostability of CGNP clusters-RGD. The error bars in e and f represent standard error of the average PA signal measured from three different animals (N = 3), p < 0.05. Source data are provided as a Source Data file.

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