Fig. 3: Chromosome compartments and TADs mainly remain unchanged after Znf143 deletion. | Nature Communications

Fig. 3: Chromosome compartments and TADs mainly remain unchanged after Znf143 deletion.

From: ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

Fig. 3

a PCA analysis for the first principle component representing compartment A and B on chr1 at 50 kb resolution. b Density plot describes global correlation between the eigenvector value from wild type (Znf143 f/f) and Znf143 depleted (Znf143 −/−) LSKs at 1 Mb resolution. The X-axis represents the eigenvector value in Znf143 f/f cells on each genome locus, while the Y-axis the value in Znf143 −/− cells in the same locus. c Comparison of TADs in wild type (Znf143 f/f) and Znf143 knockout (Znf143 −/−) cells. A snapshot of balanced contact matrices on chr1:100–130 Mb. d Mean plot describes genome-wide insulation score around TADs boundaries. The X-axis represents the genome distance to the TADs boundaries, while the Y-axis the insulation score. The 0 position on the X-axis in the left panel indicates TAD boundaries in Znf143 f/f cells, while in the right panel TAD boundaries in Znf143 −/− cells.

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