Fig. 4: Metabolic shifts are explained by temperature-induced proteome constraints.
From: Bayesian genome scale modelling identifies thermal determinants of yeast metabolism
The ATP production in the cytoplasm and the total protein amount required at different temperatures were simulated using Posterior etcGEMs with chemostat culture settings with a dilution rate of 0.1 h−1 (“Methods”). Simulation results from a the original Posterior models, b the original Posterior models with doubled total protein constraint, c the original Posterior models with increased Tm of ATP1, HEM1, and PDB1 (to 50 °C) and are shown. Lines indicate median values and shaded areas indicate the region between the 5th and 95th percentile (n = 100). Source data are provided as a Source Data file.
