Fig. 3: SIgA-Salmonella amplify Salmonella-induced colitis in mice.
From: NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn’s disease
Cohoused mice were challenged orally either with DSS, PBS, Salmonella Typhimurium or Salmonella Typhimurium bound with murine IgA. They were left untreated or treated with 5% laminarin in drinking water for 3 days prior to colitis challenge. a Disease activity index (DAI) score was undertaken daily to evaluate the clinical progression of colitis. The DAI was the combined score of weight loss compared to initial weight, stool consistency, and bleeding. Vertical bars show the mean value±SEM. n = 5 biologically independent mice per group. One-way ANOVA followed by Bonferroni post hoc test was used (p values: *p < 0.05; ***p < 0.005). b Sections from the colon of mice showing neutrophil infiltrates in the lamina propria. This experiment was repeated on all mice showing similar results. c Nancy histological score applied in each colon section for littermate and NOD2 KO mice. n = 5 biologically independent mice per group. One-way ANOVA followed by Bonferroni post hoc test was used (p values: **p < 0.01). Source data are provided as a Source Data file.
