Fig. 1: ZEB2 is expressed in injured cardiomyocytes.
From: Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
a Study design. b Area of the heart subjected to single-cell sequencing. c-d t-SNE map indicating transcriptome similarities among all individual cells. c Different numbers and colors highlight different clusters identified by K-medoids clustering. d Colors highlight the conditions of the hearts from which the cells were derived (sham in green and 3 dpMI in pink). e The PANTHER Classification System analysis on enriched genes from injured cardiomyocytes when compared to sham. f t-SNE map showing the expression of Zeb2 across all cardiomyocytes from sham and 3 dpMI hearts. g Representative confocal images from sham and ischemic mouse hearts 3 dpMI stained for ZEB2, ACTN2, and DAPI. h Representative confocal images from human control and ischemic hearts stained for ZEB2, ACTN2, and DAPI. Expression is depicted as normalized transcript count on a color-coded scale. t-SNE indicates t-distributed stochastic neighbor embedding. White arrows show ZEB2 positive cardiomyocytes.
