Fig. 4: Tmsb4 and Ptma as ZEB2 target genes.
From: Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner
a-b mRNA expression levels of a Tmsb4 and b Ptma in Zeb2 fl/fl and Zeb2 cKO mice post-surgery. c-d Immunofluorescence for c TMSB4, ACTN2, and DAPI and d PTMA, ACTN2, and DAPI of histological sections of hearts from Zeb2 fl/fl and Zeb2 cKO mice 14 dpMI. e-g mRNA expression levels of e Zeb2, f Tmsb4, and g Ptma in mice subjected to MI for different time periods. h-i 1-Pearson correlation between ZEB2 and h TMSB4 and i PTMA in human ischemic hearts. Green dashed line indicates sham Zeb2 fl/fl control. Data are represented as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, each dot indicates a biological replicate, n is indicated in figures. Comparison of two groups was performed with the unpaired, two-tailed Student’s t-test, between Zeb2 cKO vs Zeb2 fl/fl post-MI (a, b) and between sham vs MI at different time points (e, f, g). Source data are provided as a Source Data file.
