Fig. 2: Conserved and apicomplexan-specific Fo components of hexameric ATP synthase.
From: ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
a The canonical Fo subunits b, d, f, i/j, k, and 8 contain apicomplexan-specific extensions contributing to a large Fo. Subunit-a contains only the conserved H5-6a, and ATPTG16, ATPTG17 partially replace the missing H1-4a. Inset shows N-terminal helix of ATPTG11 forming a parasite-specific rotor-stator interface with the lumenal side of the c-ring. b Top view of rotor-stator interface. The absence of H1-4a separates subunit-a from several canonical Fo-subunits. Resulting lipid-filled Fo void outlined (black dash). c Cross section through the Fo region of the map. ATPTG11 extends from the lumenal region to plug the c-ring through interactions with H1TG11.
