Fig. 1: Mutation spectra in mucosal and common cutaneous melanomas.
From: Ultraviolet radiation drives mutations in a subset of mucosal melanomas
a Mutation signatures weighted by relative contribution to spectrum of mutations in individual tumor genomes. Indices above indicate mucosal (black, n = 18) or common cutaneous (red, n = 54) melanomas with subdivision into non-SBS7v2 (blue, n = 9, n = 3, respectively) and SBS7v2 (magenta, n = 9, n = 51 respectively) genomes. Columns represent individual tumors. b Relative contribution of SBS7v2 to mutation spectra (SBS7v2 Weights) for individual mucosal (MuM) or cutaneous (Cut) melanomas with SBS7v2 (magenta n = 9, gray n = 51) or non-SBSv2 (maroon n = 9, blue n = 3) genomes. c Proportion of six nucleotide transitions/transversions for individual tumor genomes (individual columns). d Proportions of C > T nucleotide transitions in individual mucosal (MuM) or cutaneous (Cut) melanomas with SBS7v2-dominant (magenta n = 9, gray n = 51) or non-SBSv2 (maroon n = 9, blue n = 3) genomes. e Total SNVs in individual mucosal (MuM, magenta, n = 18) or cutaneous (Cut, gray, n = 54) melanomas. Columns represent individual tumors. f Total SNVs in mucosal (MuM) and cutaneous (Cut) melanomas with SBS7v2-predominant (magenta n = 9, gray n = 54) or non-SBSv2 (maroon n = 9, blue n = 3) genomes. Panels b, d, f show median and 95% confidence intervals, dots denote individual tumors, P-values determined by two-tailed Mann–Whitney U, ns = not significant: 0.4140 in b, 0.8387 in d, 0.6838 in f, respectively.
