Fig. 5: Trim28 adi-KO alters triglyceride composition in WAT.
From: Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance
Lipidomics in gonadal fat pads (WAT), liver, and plasma from female mice fed a chow diet for 24 weeks. Triglyceride (TG) species from (a) WAT, (b) liver, and (c) plasma. Triglyceride species were ordered into subclasses based on the combined FA carbon chain length (i.e., TG48 = 3× FAs containing 16 C each), then sorted vertically within those subclasses according to increasing carbon bond saturation (in the order indicated by the scale bar). For a complete list of triglycerides analyzed, see Supplementary Data Table 1. Squares represent data for single ion monitoring mode (SIM) of lipid species; circles represent species with annotation of a single FA side chain as determined by neutral loss analysis (NL). Data are expressed as log10 fold change from Trim28 WT mice as mean ± SEM, n = 11 WT and n = 11 KO. Individual comparisons were analyzed using Student’s two-tailed unpaired t tests. Closed symbols represent species that were statistically significant (p < 0.05) compared to WT. TG triacylglycerol, NL neutral loss, O-TG alkyl triacylglycerols.
