Fig. 8: Scheme showing a possible role of SLC46A3 in hepatic lipid accumulation in mice.
From: Lysosomal SLC46A3 modulates hepatic cytosolic copper homeostasis
In the normal state of hepatocytes, intracellular copper levels can be balanced by homeostasis, but induction of SLC46A3 by TCDD can lead to an abnormal increase in copper migration to lysosomes. Conversely, a mild increase of copper in the cytosol may inhibit TG accumulation in liver. Thus, the lack of intracellular copper levels can result in mitochondrial dysfunction. Ultimately, lipids such as TG are stored in the form of lipid droplets. Nu Nucleus; Mito Mitochondria; Ly Lysosome; SLC SLC46A3; Cu Copper; Ld Lipid droplet; Bc Bile canaliculi.
