Fig. 3: EXTEND scores in cancer.

a EXTEND scores for TERT-expressing tumors and normal samples across 16 TCGA cancer cohorts. Violin width indicates data point density. Middle bar, median. b EXTEND scores across tumor stages (CRC = 338, HNSC = 420, KIRC = 375, KIRP = 254, LUAD = 497, STAD = 374, and THCA = 499 cases in total). Only tumor types with a minimum of ten cases for each stage were used in this analysis. P values were calculated using two-sided t test. *P < 0.05; **P < 0.01. Box indicates 25–75th quantile range. Middle bar indicates median. The minima and maxima are within 1.5 times the interquartile range of the lower and higher quartile. c EXTEND scores of cutaneous melanomas (TCGA SKCM). Violin width indicates data point density. Middle bar, median; two-sided t test. *P < 0.05; **P < 0.01. d Hazard ratio plot based on univariate Cox regression model for 31 cancer types. Vertical bars indicate upper and lower limits of the 95% confidence interval of the hazard ratio estimates. P values are highlighted for significant cases only (*P < 0.05; **P < 0.01). The y-axis is in the natural log scale. e Correlations between EXTEND scores and gene expression of ten oncogenic signaling pathways across 31 cancer types. Significant correlations (FDR < 0.05) are shown in either red (positive correlation) or blue circles (negative correlation). The frequency of each gene’s positive and negative correlation patterns across different cancer types is summarized on the right. Data used for the figure is available in Source Data.