Fig. 6: Domain boundaries are preferentially localized at insulator binding sites since MBT.
From: High-resolution single-cell 3D-models of chromatin ensembles during Drosophila embryogenesis
a Distributions of domain boundary probabilities along genomic positions of the same region in Fig. 5A (chr2L: 11.0–12.0 Mb) of three cell types are shown in the top three rows. Tracks in the 4-th to the 6-th row indicate the binding sites of 3 different insulator proteins of BEAF-32, CP190, and Chromator, respectively. The track in the 7-th row indicates the intersection of the binding sites between BEAF-32 and CP190 or between BEAF-32 and Chromator, the last track represents the intersection of the binding sites between CTCF and Smc3 (cohesin subunit). All tracks are from S2-DRSC. b Enrichment curves of the averaged domain boundary probabilities at the binding peaks of CTCF and Smc3. c Enrichment curves of the averaged domain boundary probabilities at the binding peaks of BEAF-32 and Chromator.
