Fig. 1: P2C-1F11 resembles ACE2 in binding to SARS-CoV-2 RBD.
From: Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry
a Overall structures of the SARS-CoV-2 RBD and Fab complexes. SARS-CoV-2 RBD is in cyan, P2B-2F6 Fab in yellow, P2C-1A3 Fab in blue, and P2C-1F11 Fab in magenta. The three Fab and RBD complexes are superimposed to demonstrate their relative positions and orientations. b Fab binding to RBD relative to RBD-ACE2 binding. The dashed and solid red lines indicate the long axes of Fabs and ACE2, respectively, in binding to RBD. Angles between the two are indicated. The three Fab and SARS-CoV-2 RBD complexes are superimposed to demonstrate their positions and orientations relative to ACE2. c The footprint of Fabs and ACE2 on SARS-CoV-2 RBD. Yellow, blue, magenta and green represent the footprint of P2B-2F6 Fab, P2C-1A3 Fab, P2C-1F11 Fab, and ACE2, respectively. Binding residues shared between each of the Fab and ACE2 are listed in the lower panel.
