Fig. 1: Structural events in smoldering multiple myeloma (SMM) compared to newly diagnosed myeloma (MM). | Nature Communications

Fig. 1: Structural events in smoldering multiple myeloma (SMM) compared to newly diagnosed myeloma (MM).

From: The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

Fig. 1

a Frequency of cytogenetic subgroups and main translocations in SMM and MM suggesting that fewer SMM have high-risk features. b Circos plot of the landscape of non-Ig-MYC and non-canonical Ig translocations highlighting FAM46C and TXNDC5 as current recurrent partners. c Copy-number changes in 160 recurrently altered regions covering the known drivers (Supplemental Table 4) in SMM and MM suggesting the landscape is similar but there are fewer copy-number abnormalities. Adverse translocations = t(4;14), t(14;16), t(14;20). Favorable cytogenetics = t(11;14), HRD.

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