Fig. 5: Acquisition of drivers in SMM patients over time. | Nature Communications

Fig. 5: Acquisition of drivers in SMM patients over time.

From: The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

Fig. 5

a Swimmer plot of the group of patients (A–G) followed over time. The color bars represent progression-free survival. b Plot showing changes in copy number over time with a focus on the loss of del(5) and the acquisition of gain(1q), del(11q), and del(13). Arrows highlight changes in CNA. c The acquisition of a t(8;14) within a myeloma propagating cell leads to outgrowth of the clone until it dominates the tumor population. EM early myeloma, FU follow-up, NDMM newly diagnosed myeloma, NGS next-generation sequencing, MS M-spike.

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