Fig. 1: Plots for genome-wide association analysis results for daytime napping in the UK Biobank (n = 452,633) and replication in 23andMe (n = 541,333).
From: Genetic determinants of daytime napping and effects on cardiometabolic health
A Manhattan plot of daytime napping genome-wide association study in the UK Biobank (n = 452,633). Plot shows the −log10P values (y-axis) for all genotyped and imputed single-nucleotide polymorphisms (SNPs) passing quality control (BOLT-LMM mixed-model association test P values) ordered by chromosome and base position (x-axis). Blue peaks represent genome-wide significant loci. Horizontal red line denotes genome-wide significance (P = 5 × 10−8). Top 8 loci are annotated with nearest gene. B Daytime napping signals’ effect estimates from UK Biobank (n = 452,633) plotted against effect estimates from 23andMe (n = 541,333). Error bars represent the 95% confidence intervals for each effect estimate. C Effect estimates of daytime napping signals from UK Biobank and 23andMe meta-analysis (total n = 993,966) plotted against minor allele frequency.
