Fig. 4: Genome-wide genetic architecture of daytime napping correlations and associations with diseases and traits.
From: Genetic determinants of daytime napping and effects on cardiometabolic health
A Shared genetic architecture between daytime napping and cardiometabolic diseases and traits. Linkage disequilibrium (LD) score regression estimates of genetic correlation (rg) were obtained by comparing genome-wide association estimates for daytime napping (without and with BMI adjustment) with summary statistics estimates from 257 publicly available genome-wide association studies. Blue indicates positive genetic correlation and red indicates negative genetic correlation; rg values are displayed for significant correlations. Larger colored squares correspond to more significant P values. Asterisk denotes significant false discovery rate (FDR) corrected P values. Full genetic correlations for all 257 traits can be found in Supplementary Data 10. B Manhattan plot of phenome-wide association findings for daytime napping genome-wide polygenic score in Mass General Brigham Biobank (n = 23,561). The x-axis is color-coded phecodes organized by broad disease categories and the y-axis is P value of association (−log10 P). The horizontal red line depicts phenome-wide significance using Bonferroni correction for all tested diseases (951 diseases), and the horizontal blue line depicts phenome-wide significance using FDR correction. Upward arrows denote positive associations (OR > 1), and downward arrows denote inverse associations (OR < 1). Full results for all 951 diseases can be found in Supplementary Data 11. C Cross-sectional association between quartile 10 and quartile 1 (reference group) of daytime napping genome-wide polygenic score and essential hypertension, obesity, and chronic nonalcoholic liver disease in the Mass General Brigham Biobank (n = 23,561). Error bars represent the 95% confidence intervals for association.
