Fig. 5: Local administration of IL-12:Fc results in minimal systemic effects. | Nature Communications

Fig. 5: Local administration of IL-12:Fc results in minimal systemic effects.

From: Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Fig. 5

Serum cytokines and chemokines were measured by cytokine bead array (CBA, Legendplex) at day 4 and 11 post IL-12:Fc administration. A IL-12, B IFN-γ, C CXCL9, D CXCL10, E IL-6, and F GM-CSF (NT+PBS n = 4, NT+IL-12:Fc n = 5, CAR+PBS n = 4, CAR+IL-12:Fc n = 5 mice from one experiment). Plots show mean ± SEM. Ordinary Two-way Anova with Tukey’s multiple comparison test. Source data are provided as a Source Data file.

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