Fig. 1: Striatal epigenetic alterations induced by the HD mutation establish early and in cell-type-dependent manner in HD Q140 mice. | Nature Communications

Fig. 1: Striatal epigenetic alterations induced by the HD mutation establish early and in cell-type-dependent manner in HD Q140 mice.

From: Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

Fig. 1

a UCSC genome browser capture showing representative H3K27ac, H3K27me3 and RNAPII signals in the striatum of WT and Q140 mouse striatum at 2 and 6 months at selected locus, including active (Darpp32 (Ppp1r1b)) and repressed (Neurod2) genes in the adult striatum. 2 mo., 2 months; 6 mo., 6 months b Gene Ontology analysis of regions differentially enriched in H3K27ac and RNAPII between Q140 and WT mouse striatal samples at 2 months (FDR < 0.05). Significant biological processes are shown using dot size proportional to gene ratio and heatmap reflecting adjusted P value. c UCSC genome browser capture showing representative H3K27ac and H3K27me3 signals in striatal NeuN+ and NeuN− populations in WT mice at 6 months at selected neuronal gene (NeuN (Rbfox3)) and glial gene (Olig2). d Bargraphs showing cell-type distribution of regions differentially enriched in H3K27ac in Q140 vs WT mouse striatum at 2 and 6 months of age. e Metaprofiles showing H3K27ac signal in NeuN+ and NeuN− sorted nuclei, considering differentially enriched peaks in Q140 vs WT striata at 2 months. Source data are provided as a Source Data file.

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