Fig. 7: Local molecular environment of the bound heme in the ancestral protein.
From: Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase

a Schematic representation of the heme molecule and the neighbor residues in the 3D structure. b Heme group and residues directly interacting with the heme colored by B value. c Van der Waals surface of the ancestral protein shown in translucent brown, so that it becomes visually apparent that the heme (shown in red) is mostly buried.