Fig. 3: CREPT is required for intestinal epithelium regeneration after X-ray irradiation.
From: CREPT is required for murine stem cell maintenance during intestinal regeneration
a Schematic diagram showing irradiation and analysis schedule. b The Kaplan-Meier survival curve of irradiated Vil-CREPTWT and Vil-CREPTKO mice with p = 0.0004 by one-sided log-rank test. n = 13 WT mice and n = 11 Vil-CREPTKO mice. c Representative H&E-stained, Olfm4-stained, and Ki67-stained sections of small and large intestines from Vil-CREPTWT and Vil-CREPTKO mice at different time after 10 Gy X-ray radiation. Images are representative of at least three animals for each condition. d Quantification of regenerated crypts per 1 mm small intestine marked by Olfm4 at 5 dpi. p < 0.0001 by 2-tailed Student’s t-test. n = 3 independent experiments. e Quantification of regenerated crypts per 1 mm colon marked by Ki67 at 5 dpi. p < 0.0001 by 2-tailed Student’s t-test. n = 3 independent experiments. Statistics data represent mean ± SEM. Scale bars, 100 μm.
