Fig. 7: A graphical model of CREPT function in ISCs and intestinal regeneration. | Nature Communications

Fig. 7: A graphical model of CREPT function in ISCs and intestinal regeneration.

From: CREPT is required for murine stem cell maintenance during intestinal regeneration

Fig. 7

ISCs reside in intestinal crypts. CREPT maintains the proliferation and differentiation of Lgr5+ ISCs at homeostasis. Under damages such as irradiation, CREPT promotes the activation of the Wnt signaling pathway through facilitating β-catenin retention in the nucleus. CREPT is indispensable for intestinal regeneration, and the deletion of CREPT leads to impaired proliferation ability of ISCs and failure of intestinal regeneration.

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