Fig. 1: Experimental design and convalescent plasma infusion.
From: SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
A Rhesus macaques inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were infused with COVID-19 convalescent plasma (I + CP), normal plasma (I + NP), or did not receive plasma (infected). B Concentrations of human IgG antibodies against S1, S2, and N following CP infusion. C Concentrations of human IgM and IgG antibodies against S1, S2, and N in pooled CP pre-infusion. Pseudovirus neutralization of CP pre-infusion and pooled macaque sera post infusion. D Mean viral RNA (+SD) in nasal washes (kinetic data shown derived from independent animals, sample size for experimental groups: n = 4 infected, n = 2 I + CP, and n = 2 I + NP).
