Fig. 4: Application to chemical synthesis and collective synthesis of seven biologically active compounds. | Nature Communications

Fig. 4: Application to chemical synthesis and collective synthesis of seven biologically active compounds.

From: Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Fig. 4

a Our APS reaction was applied to the two-step enantioselective synthesis of (−)-Thiohexital. b The current methodology could allow for the rapid and enantioselective production of (+)-Thiopental and (+)-Pentobarbital. c The feasibility of the APS reaction was evaluated in the total synthesis of (−)-AMG 837. d The APS reaction provided facile access to (+)-Phenoxanol, (+)-Citralis, and (−)-Citralis Nitrile.

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