Fig. 5: Mechanistic studies. | Nature Communications

Fig. 5: Mechanistic studies.

From: Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel/Lewis acid-catalyzed propargylic alkylation

Fig. 5

a Radical scavenger experiments. b Kinetic studies. The dependence of the reaction rate by varying the Lewis acid additives. c Nonlinear relationship between the optical activity of phosphine ligand L1 and propargylated adduct 3v. d Plausible stereochemical model. TEMPO 2,2,6,6-tetramethylpiperidinyloxy, BHT butylated hydroxytoluene, 1,4-CHD 1,4-cyclohexadiene.

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