Fig. 7: Frequencies of follicular helper T cell (Tfh) and germinal center (GC) B cells generated by immunization with NVX-CoV2373 and Matrix-M adjuvant. | Nature Communications

Fig. 7: Frequencies of follicular helper T cell (Tfh) and germinal center (GC) B cells generated by immunization with NVX-CoV2373 and Matrix-M adjuvant.

From: SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Fig. 7

Mice were immunized with NVX-CoV2373 with and without Matrix-M adjuvant and splenocytes were collected 7 days after the second immunization. a The frequency of splenic Tfh cells (CXCR5+ PD-1+ CD4+) in the CD4 T population. b The frequency of splenic germinal center (GC) B cells (GL7+ CD95+ CD19+) in B cells. Bars represent the mean values and the error bars indicate ±SD of triplicate assays. Colored symbols indicate individual animal values. Comparisons between groups receiving NVX-CoV2373 with and without adjuvant was performed by Student’s t-test (unpaired, two tail). Source data are provided as a Source Data file.

Back to article page