Fig. 3: Sustained CPSF expression in undifferentiated keratinocytes requires MYC. | Nature Communications

Fig. 3: Sustained CPSF expression in undifferentiated keratinocytes requires MYC.

From: Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration

Fig. 3

a Genome browser tracks showing the binding of MYC at CPSF1 promoter in keratinocytes as well as in MCF7 cells (GSE32883). b Western blots showing the downregulation of MYC during keratinocyte differentiation. Quantification of MYC protein level fold change is indicated below (n = 3). c Western blotting showing the knockdown efficiency of shRNAs targeting MYC. Quantification is indicated below (n = 3). d, e qRT-PCR quantification of MYC and CPSF1 comparing MYC knockdown versus control. Dots represent data points in technical replicates. Source data are provided as a Source Data file.

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