Fig. 5: Testing and tracing give rise to two TTI-stabilized regimes of spreading dynamics. | Nature Communications

Fig. 5: Testing and tracing give rise to two TTI-stabilized regimes of spreading dynamics.

From: The challenges of containing SARS-CoV-2 via test-trace-and-isolate

Fig. 5

In addition to the intrinsically stable regime of the simple SIR model (blue region), our model exhibits two TTI-stabilized regimes that arise from the isolation of formerly “hidden” infected individuals uncovered through symptom-based testing alone (green region) or additional contact tracing (amber region). Due to the external influx, the number of observed new cases reaches a nonzero equilibrium \({\hat{N}}_{\infty }^{\,\text{obs}\,}\) that depends on the hidden reproductive number (colored lines). These equilibrium numbers of new cases diverge when approaching the respective critical hidden reproductive numbers (\({R}_{\,\text{crit}\,}^{H}\)) calculated from linear stability analysis (dotted horizontal lines). Taking into account a finite tracing capacity \({N}_{\max }\) shrinks the testing-and-tracing stabilized regime and makes it metastable (dotted amber line). Note that, for our standard parameter set, the natural base reproduction number R0 lies in the unstable regime. Please see Supplementary Fig. 5 for a full phase diagram and Supplementary Note 1 for the linear stability analysis.

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