Fig. 1: Histone modification and chromatin accessibility landscapes of primary LSCs.
From: Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
a Phase contrast image and immunofluorescence staining of primary LSCs for the indicated marker genes. Scale bar, 100 μm. b Heatmaps grouped into two clusters by k-means algorithm for ATAC-seq and the indicated ChIP-seq signals at the centers of ATAC peaks in LSCs. c Ranked enhancer plots defined by H3K27ac. Enhancers above the inflection point of the curve have exceptionally strong H3K27ac signals and are defined as SEs. The selected genes are SE-associated genes. d Metaplots of average ATAC-seq, H3K4me1, and H3K27me3 density at TEs (left) and SEs (right) in LSCs. e Genome browser tracks for H3K27ac, H3K4me1, H3K27me3, and ATAC-seq signals at the indicated SE loci. f GO biological process (BP) analysis of SE-associated genes with pvalueCutoff = 0.01 and qvalueCutoff = 0.05.
