Fig. 2: CRC model characterizes LSC-specific TF network.
From: Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
a Interaction network between TFs and SEs in LSCs. Each node is colored according to expression level (log2 TPM), and each node size is scaled according to total degree. Edges indicated in gray represent predicted interactions between TFs and SEs. The turquoise edges represent auto-regulatory loops. TPM: transcripts per kilobase million. b Scatter plot of in-degree (number of TFs binding to the SE of a node gene) and out-degree (number of SEs bound by a node TF) for genes in the SE-mediated regulatory network. c A TP63-centered network showing the SE-based regulatory relationships. d Genome browser tracks for the indicated histone modifications and ATAC signals at the indicated SE loci with logos and positions of the enriched TF motifs shown. e Clique enrichment score of each CRC TF calculated as the percentage of total cliques in which that TF is a constituent member. f Immunofluorescence staining of the indicated genes in normal adult human cornea and limbus. Scale bars, 200 μm. g Enrichment of RPS motifs at SEs, TEs, and ATAC peaks. h Genome browser tracks for the indicated ChIP-seq and ATAC-seq signals across the indicated SE loci in LSCs. i A CRC model established by RPS.
