Fig. 4: RPS complex positively regulates SE activity.
From: Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis
a Hierarchical clustering of the indicated ChIP-seq-binding profiles using affinity (read count) scores. Pearson correlation coefficients between each group are shown. b Motif enrichment within RPS peaks in LSCs. c Co-immunoprecipitation analysis of the interactions among endogenous RUNX1, PAX6, and pSMAD3 in LSCs. d Heatmaps grouped into two clusters using k-means algorithm for the indicated ChIP-seq and ATAC-seq signals at RUNX1-bound sites. e Metaplots of average RPS ChIP-seq signals across TEs and SEs in LSCs. f GSEA of SE-associated gene set in scrambled shRNA-treated versus shRUNX1-treated LSCs and scrambled shRNA-treated versus shSMAD3-treated LSCs. g Venn diagram showing the overlapping and unique peaks bound by RPS. h Genome browser tracks for the indicated ChIP-seq and ATAC signals across the TGFBI, AQP3, and IGF1R loci. i GO BP and KEGG analysis for the genes closest to the overlapping RPS peaks with pvalueCutoff = 0.01 and qvalueCutoff = 0.05.
