Fig. 4: Synthetic applications.

a Gram-scale operation of the BzO-DFs synthesis and the subsequent Ni-catalyzed arylation. b Exploration of the coupling partners with the BzO-DF building blocks: catalytic protocols based on the uses of organometallic nucleophiles such as organomagnesium/-zinc and organotrifluoroborates as well as electrophiles such as benzyl chlorides have been developed. ^a1a (1.46 g) was used at starting material. ^b3a (0.46 g) was used for the Ni-catalyzed coupling reaction. ^cNMR yield determined by ¹⁹F NMR with trifluorotoluene as internal standard. ^dIsolated yields.