Fig. 2: The GATA2 binding motif and occupancy are enriched at the accessible regions within the super-enhancers of the key mast cell identity genes. | Nature Communications

Fig. 2: The GATA2 binding motif and occupancy are enriched at the accessible regions within the super-enhancers of the key mast cell identity genes.

From: GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Fig. 2

a Representative tracks of the key ID genes and non-ID genes. b Enrichment analysis of TF binding motifs at the accessible regions, TEs and SEs separately or in the overlapped regions between the accessible regions and TEs or between the accessible regions and SEs. TF binding motif enrichment was also analyzed for the peaks from GATA2 ChIP-seq (GATA2-bound sites). NA means unknown motifs. c The numbers of GATA2 and MITF motifs per gene. d Representative tracks for the key ID and non-ID genes. e The GATA2 and MITF occupancy. Total per gene indicates the number of average bound sites and reads per gene. Data (a-e) represent two biological samples. f The regulatory potential scores calculated using GATA2-bound sites (upper panel) (n = 3 biologically independent samples). The RNA transcripts (lower panel). RPKM, reads per kilobase per million mapped reads. Data represent three biological samples. P-values were calculated by a two-tailed student’s t test without adjustments. The IGV tracks are generated from one biological sample, representing two biological replicates with similar patterns. Middle line inside each box represents the median, upper and lower bounds of the box represent the third and first quartiles, respectively. Whiskers represent 1.5 times of the interquartile range.

Back to article page