Fig. 3: GATA2 promotes chromatin accessibility and H3K4me1 and H3K27ac modifications of histones associated with the MC genes. | Nature Communications

Fig. 3: GATA2 promotes chromatin accessibility and H3K4me1 and H3K27ac modifications of histones associated with the MC genes.

From: GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Fig. 3

a Calculated average reads at enhancers for the key ID genes and the non-ID genes in wild-type MCs (WT) and Gata2−/− MCs (KO). Middle line inside each box represents the median, upper and lower bounds of the box represent the third and first quartiles, respectively. Whiskers represent 1.5 times of the interquartile range. P-values were calculated by a two-tailed student’s t test without adjustments. b Heatmap presentation of reads at the enhancers (FPKM) and RNA reads (RPKM). c Representative tracks. Data a–c represent two biological samples. The IGV tracks are generated from one biological sample, representing two biological replicates with similar patterns.

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