Fig. 4: IgE receptor crosslinking induces expression of genes that encode signaling molecules, Proteases and enzymes, transcription factors, MC surface molecules, cytokines and chemokines. | Nature Communications

Fig. 4: IgE receptor crosslinking induces expression of genes that encode signaling molecules, Proteases and enzymes, transcription factors, MC surface molecules, cytokines and chemokines.

From: GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Fig. 4

a Heatmap presentation of the RNA transcripts after IgE receptor crosslinking for two hours. Unstim: unstimulated; Stim: stimulated. “Highly induced” means that the fold of induction (Stim vs Unstim) is higher than 10, “induced” means that the fold of induction ranges from 2 to 10, “unchanged” means that the fold of change is higher than 0.5 and lower than 2 and “repressed” means that the fold of change is lower than 0.5. b DAVID gene ontology enrichment analysis of the activation-induced genes. P-values were calculated by a one-side Fisher’s exact test with the adjustment of Benjamini-Hochberg method. c Heatmap representations of top activation-induced genes. The numbers indicate RNA reads (RPKM). Data a–c represent three biological samples.

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