Fig. 6: Promoter-hubs do not show synergy. | Nature Communications

Fig. 6: Promoter-hubs do not show synergy.

From: High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

Fig. 6

a 4sU-seq measured expression of genes with promoters classified by GenoSTAN as having weak H3K27ac (PW), strong H3K27ac (PS), or a CTCF (PC). b Boxplots of interacting elements for each promoter class show 10th percentile (lower whister), 25th percentile, median, 75th percentile and 90th percentile (upper whisker). For a and b, p-values are for a two-sided Kruskal–Wallis test with Dunn’s multiple test correction. n = 5498 PW, 403 PS, and 1905 PC promoter viewpoints. c Expression of genes that do not interact with enhancers grouped according to the number of promoters that they interact with. An equivalent analysis for genes that interact with enhancers is in Supp. Fig. 31. Source data are available in the Source Data file.

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