Fig. 5: Inhibition of TNF signalling in cells.

Representative concentration–response curves showing the effect of UCB-9260 on signalling in an NFκβ reporter cell assay driven by 10 pM hTNF (blue trace), 100pM hTNF (green trace) and anti-TNFR1 antibody at 300 ng/mL (red trace). Source data are provided as a Source Data file.