Fig. 6: Model of TNF–TNFR1 signalling network. | Nature Communications

Fig. 6: Model of TNF–TNFR1 signalling network.

From: Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

Fig. 6

a Schematic representation of TNFR1 dimers (pink and purple) pre-clustered, with a portion bound to TNF (green) (two copies of TNFR1 dimer bound per TNF trimer). Addition of more TNF (green) results in linking of the TNF-two-receptor-bound units into larger TNF-three-receptor-bound clusters finally assembling into a large network. b Same scenario as a in the presence of compound (yellow dots), resulting in incomplete network assembly.

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