Fig. 6: Heterogenous tuning to eye velocity.
From: Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals
ai Model-derived tuning curves (mean ± sem of 10 model folds) for cells significantly encoding horizontal eye velocity (\(\dot E_{h}\); Supplementary Figs. 5–8). The stability (“S”) and tuning curve class is indicated at top (Las, linear-asymmetric; NLas, nonlinear-asymmetric; NLs, nonlinear-symmetric; Pos, positive; Neg, negative). aii Bottom: Spiking from an \(\dot E_{h}\)-encoding cell. Gray trace, Eh. Black dots, spikes. Top: The associated tuning curve. aiii Summary tuning curve classes. Bar color indicates nasal/temporal preference. aiv Cells’ sensitivity in the temporal versus nasal rotational ranges. Units = spikes/s/normalized eye width/s. av Stability of tuning to \(\dot E_{h}\). Boxplots: linear-asymmetric and nonlinear-asymmetric cells were significantly more stable than nonlinear-symmetric cells (median [1st–3rd quartile]; Las = 0.96 [0.91–0.99]; NLas = 0.94 [0.87–0.98]; NLs = 0.86 [0.72–0.93]; Χ2 = 19.30, P = 6.4e−5, df = 2; Las versus NLas, P = 0.12, Las versus NLs, P = 0.00028, NLas versus NLs, P = 0.00012; Kruskal–Wallis test with two-sided post hoc Wilcoxon rank-sum comparisons with α = 0.0167 after Bonferroni correction for multiple comparisons). bi Tuning curves for cells significantly encoding vertical eye velocity (\(\dot E_v\)). bii Spiking from an \(\dot E_{v}\)-encoding cell. biii Summary of tuning curve classes. Bar color indicates upward/downward preference. biv Cells' sensitivity in the upward versus downward velocity ranges. Units = spikes/s/normalized eye width/s. bv Stability of tuning to \(\dot E_v\). Boxplots: nonlinear-asymmetric cells were significantly more stable than nonlinear symmetric cells (median [1st–3rd quartile]; Las = 0.55 [0.18–0.87]; NLas = 0.85 [0.51–0.96]; NLs = 0.38 [0.02–0.81]; Χ2 = 11.37, P = 0.0034, df = 2; Las versus NLas, P = 0.048, Las versus NLs, P = 0.33, NLas versus NLs, P = 0.0014; Kruskal–Wallis test with post hoc two-sided Wilcoxon rank-sum comparisons with α = 0.0167 after Bonferroni correction for multiple comparisons). Boxplots: box, interquartile range; solid line, median; whiskers, range; outliers plotted separately.
